Endoplasmic Reticulum Stress and Inflammation
نویسندگان
چکیده
منابع مشابه
Endoplasmic reticulum stress and inflammation.
Endoplasmic reticulum (ER) stress due to the presence of misfolded or unfolded proteins in the ER invokes a fundamental biological response, termed the unfolded protein response (UPR). The UPR is orchestrated by three main proximal effectors, of which the IRE1/XBP1 pathway represents the evolutionarily most conserved one. Due to its high secretory burden, the intestinal epithelium is highly sus...
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Endoplasmic Reticulum (ER) stress, caused by disturbance in ER homeostasis, has been implicated in several pathological conditions such as ischemic injury, neurodegenerative disorders, metabolic diseases and more recently in inflammatory conditions. Our present study aims at understanding the role of ER stress in endothelial cell (EC) inflammation, a critical event in the pathogenesis of acute ...
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ژورنال
عنوان ژورنال: Digestive Diseases
سال: 2012
ISSN: 1421-9875,0257-2753
DOI: 10.1159/000338121